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Selected Publications











Dr. Yuan Lin




Dr. Lin joined the Department of Mechanical Engineering in the University of Hong Kong in 2008 after serving a brief appointment at Brown University as a post-doctoral research associate.






















Dr. Lin obtained a MS degree in Applied Mathematics in 2006 from Brown University, followed by a Ph.D. degree in Solid Mechanics in 2007.





































Dr. Lin received the BS and MS degrees in Engineering Mechanics from Tsinghua University in 1999 and 2001, respectively.








































Selected Publications

C. Fang, F. Zheng, J. Yao, X. Wei, C. Fu, X. Shi and Y. Lin*. 2020. A Model for Bridging Microtubule Dynamics with Nuclear Envelope Shape Evolution during Closed Mitosis. Journal of the Mechanics and Physics of Solids. 144: 104116.

H. Liu, C. Fang, Z. Gong, R.C.C. Chang, J. Qian, H. Gao and Y. Lin*. 2020. Fundamental Characteristics of Neuron Adhesion Revealed by Forced Peeling and Time-Dependent Healing. Biophysical Journal. 118: 1811-1819.

P. Wen, X. Wei, and Y. Lin*. 2020. A computational model for capturing the distinct in- and out-of-plane response of lipid membranes. Acta Mechanica Sinica. In Press.

H. Lee, Z. Gan, M. Chen, S. Min, J. Yang, Z. Xu, X. Shao, Y. Lin, W.-D. Li and J.T. Kim. 2020. On-Demand 3D Printing of Nanowire Probes for High-Aspect-Ratio Atomic Force Microscopy Imaging. ACS Applied Materials & Interfaces. 12: 46571–46577.

X. Shao, M.H. Sorensen, X. Xia, C. Fang, T.H. Hui, R.C.C. Chang, Z. Chu and Y. Lin*. 2020. Beading of injured axons driven by tension- and adhesion-regulated membrane shape instability. Journal of the Royal Society Interface. 17: 20200331.

Z. Gong, C. Fang, R. You, X. Shao, R.C.C. Chang and Y. Lin*. 2020. Forced peeling and relaxation of neurite governed by rate-dependent adhesion and cellular viscoelasticity. Extreme Mechanics Letters. 40: 100902.

T.H. Hui, X. Shao, D.W. Au, W.C. Cho and Y. Lin*. 2020. Detection of the mesenchymal-to-epithelial transition of invasive non-small cell lung cancer cells by their membrane undulation spectra. RSC Advances. 10: 29999-30006.

Y. Zhang, Z. Yan, X. Xia and Y. Lin*. 2020. A Novel Electroporation System for Living Cell Staining and Membrane Dynamics Interrogation. Micromachines. 111: 767.

X. Shao, R. You, T.H. Hui, C. Fang, Z. Gong, Z. Yan, R.C.C. Chang, V.B. Shenoy and Y. Lin*. 2019. Tension- and Adhesion-Regulated Retraction of Injured Axons. Biophysical Journal. 117: 193-202.

B. Gong, J. Lin, X. Wei, J. Qian and Y. Lin*. 2019. Cross-linked biopolymer networks with active motors: Mechanical response and intra-network transport. Journal of the Mechanics and Physics of Solids. 127: 80-93.

T.H. Hui, W.C. Cho, H.W. Fong, M. Yu, K.W. Kwan, K.C. Ngan, K.H. Wong, Y. Tan, S. Yao, H. Jiang, Z. Gu and Y. Lin*. 2019. An electro-osmotic microfluidic system to characterize cancer cell migration under confinement. Journal of the Royal Society Interface. 16: 20190062.

B. Gong, X. Wei, J. Qian and Y. Lin*. 2019. Modeling and Simulations of the Dynamic Behaviors of Actin-Based Cytoskeletal Networks. ACS Biomaterials Science & Engineering. 5: 3720-3734.

Z. Gong, C. Fang, R. You, X. Shao, X. Wei, R.C.C. Chang and Y. Lin*. 2019. Distinct Relaxation Timescales of Neurites Revealed by Rate-dependent Indentation, Relaxation and Micro-rheology Tests. Soft Matter. 15: 166-174 (Journal cover article).

Z. Gong, S.E. Szczesny, S.R. Caliari, E.E. Charrier, O. Chaudhuri, X. Cao, Y. Lin*, R.L. Mauck, P.A. Janmey, J.A. Burdick and V.B. Shenoy*. 2018. Matching Material and Cellular Timescales Maximizes Cell Spreading on Viscoelastic Substrates. Proceedings of the National Academy of Sciences. 115: E2686-E2695.

T.H. Hui, Y.H. Tang, Z. Yan, T.C. Yip, H.W. Fong, W.C. Cho, K.C. Ngan, H.C. Shum and Y. Lin*. 2018. Cadherin- and Rigidity-Dependent Growth of Lung Cancer Cells in a Partially Confined Microenvironment. ACS Biomaterials Science & Engineering. 4: 446-455.

T.H. Hui, X. Wei and Y. Lin*. 2018. Interrogating the Electromechanical Regulation of Cellular Volume at the Single-Cell Level. Biophysical Journal. 114: 2030-2031.

Z. Yan, T.H. Hui, H.W. Fong, X. Shao, W.C. Cho, K.C. Ngan, T.C. Yip and Y. Lin*. 2018. An electroporation platform for Erlotinib resistance screening in living non-small cell lung cancer (NSCLC) cells. Biomedical Physics & Engineering Express. 4: 027001.

L. Yang, Z. Gong, Y. Lin*, V. Chinthapenta, Q. Li, T.J. Webster and B.W. Sheldon. 2017. Disordered Topography Mediates Filopodial Extension and Morphology of Cells on Stiff Materials. Advanced Functional Materials. 1702689.

C. Fang, T.H. Hui, X. Wei, X. Shao and Y. Lin*. 2017. A combined experimental and theoretical investigation on cellular blebbing. Scientific Reports. 7: 16666.

B. Chong, Z. Gong and Y. Lin*. 2017. Modeling the adhesive contact between cells and a wavy extracellular matrix mediated by receptor-ligand interactions. Journal of Applied Mechanics. 84: 011010.

X. Cao, E. Ban, B.M. Baker, Y. Lin, J.A. Burdick, C.S. Chen and V.B. Shenoy. 2017. Multiscale model predicts increasing focal adhesion size with decreasing stiffness in fibrous matrices. Proceedings of the National Academy of Sciences. 114: E4549-E4555.

J. Qian, J. Lin, G.-K. Xu, Y. Lin* and H. Gao. 2017. Thermally assisted peeling of an elastic strip in adhesion with a substrate via molecular bonds. Journal of the Mechanics and Physics of Solids. 101: 197-208.

Q. Zhu, F. Zhang, A.P. Liu, J. Qian, C. Fu and Y. Lin*. 2016. Shape transformation of the nuclear envelope during closed mitosis. Biophysical Journal. 111: 2309-2316 (Featured article).

T.H. Hui, K.W. Kwan, T.T.C. Yip, H.W. Fong, K.C. Ngan, M. Yu, S. Yao, A.H.W. Ngan and Y. Lin*. 2016. Regulating the membrane transport activity and death of leukemia and epithelial cancer cells via electro-osmotic manipulation. Biophysical Journal. 110: 2769-2778.

T.H. Hui, Z.L. Zhou, H.W. Fong, R. K.C. Ngan, T.Y. Lee, S.K. Au, A.H.W. Ngan, T.T.C. Yip and Y. Lin*. 2016. Characterizing the malignancy and drug resistance of cancer cells from their membrane resealing response. Scientific Reports. 6: 26692.

Z. Gong, R. You, R.C.C. Chang and Y. Lin*. 2016. Viscoelastic response of neural cells governed by the deposition of amyloid-ß peptides (Aß). Journal of Applied Physics. 119: 214701.

X. Wei, Q. Zhu, J. Qian, Y. Lin* and V. B. Shenoy. 2016. Response of biopolymer networks governed by the physical properties of cross-linking molecules. Soft Matter. 12: 2537-2541 (Journal cover article).

T. H. Hui, F. Zheng, Y. Lin* and C. Fu. 2016. The linear and rotational motions of the fission yeast nucleus are governed by the stochastic dynamics of spatially distributed microtubules. Journal of Biomechanics. 49: 1034-1041.

X. Cao, Y. Lin, T.P. Driscoll, J. Franco-Barraza, E. Cukierman, R.L. Mauck and V.B. Shenoy. 2015. A chemo-mechanical model for extracellular matrix and nuclear rigidity regulated size of focal adhesion plaques. Biophysical Journal. 109: 1807-1817.

H. Jiang, J. Qian, Y. Lin, Y. Ni and L. He. 2015. Aggregation dynamics of molecular bonds between compliant materials. Soft Matter. 11: 2812-2820.

T.H. Hui, Z.L. Zhou, J. Qian, Y. Lin*, A.H.W. Ngan and H. Gao. 2014. Volumetric Deformation of Live Cells Induced by Pressure-Activated Cross-Membrane Ion Transport. Physical Review Letters. 113: 118101.

T.H. Hui, Q. Zhu, Z.L. Zhou, J. Qian and Y. Lin*. 2014. Probing the coupled adhesion and deformation characteristics of suspension cells. Applied Physics Letters. 105: 073703.

J. Lin, Y. Lin and J. Qian. 2014. Statistical Pull-off of Nanoparticles Adhering to Compliant Substrates. Langmuir. 30: 6089-6094.

Y. Lin*, X. Wei, J. Qian, K.Y. Sze and V.B. Shenoy. 2014. A combined finite element-Langevin dynamics (FEM-LD) approach for analyzing the mechanical response of bio-polymer networks. Journal of the Mechanics and Physics of Solids. 62: 2-18.

J. Lin, Y. Lin, H. Jiang and H. Yao. 2013. Bond formation of surface-tethered receptor-ligand pairs in relative separation. Applied Physics Letters. 103: 223702.

J. Qian, H. Liu, Y. Lin*, W. Chen and H. Gao. 2013. A Mechanochemical Model of Cell Reorientation on Substrates under Cyclic Stretch. PLoS ONE. 8: e65864.

W. Zhang, Y. Lin, J. Qian, W. Chen and H. Gao. 2013. Tuning Molecular Adhesion via Material Anisotropy. Advanced Functional Materials. 23: 4729-4738.

B. Hu, V.B. Shenoy and Y. Lin*. 2012. Buckling and enforced stretching of bio-filaments. Journal of the Mechanics and Physics of Solids. 60: 1941-1951.

Y. Lin* and S. Yao. 2012. Conformation and Confinement Energy of Interacting End-grafted Molecules. International Journal of Applied Mechanics. 4: 1250008.

K.Y. Ng, Y. Lin* and A.H.W. Ngan. 2011. Compression of Micron-sized Pillars of Anodic Aluminium Oxide Nano-honeycomb.  Journal of the Mechanics and Physics of Solids. 59: 251-264.

L. Bai and Y. Lin*. 2011. Transient state model of actin-based motility. Theoretical and Applied Mechanics Letters. 1: 014002.

Y. Lin*, V.B. Shenoy, B. Hu and L. Bai. 2010. A Microscopic Formulation for the Actin-Driven Motion of Listeria in Curved Paths. Biophysical Journal. 99: 1043-1052.

Y. Lin. 2010. A model of cell motility leading to biphasic dependence of transport speed on adhesive strength.  Journal of the Mechanics and Physics of Solids. 58: 502-514.

J. Qian, J. Wang, Y. Lin and H. Gao. 2009. Lifetime and strength of periodic bond clusters between elastic media under inclined loading. Biophysical Journal. 97: 2438-2445.

Y. Lin. 2009. Mechanics model for actin-based motility. Physical Review E. 79: 021916.

K.Y. Ng, Y. Lin and A.H.W. Ngan. 2009. Deformation of anodic aluminum oxide nano-honeycombs during nanoindentation. Acta Materialia. 57: 2710-2720.

Y. Wu, G.L. Chen, X. D. Hui, C.T. Liu, Y. Lin, X.C. Shang and Z.P. Lu. 2009. A quantitative link between microplastic instability and macroscopic deformation behaviors in metallic glasses. Journal of Applied Physics. 106: 083512.

Y. Lin* and L.B. Freund. 2008. Optimum size of a molecular bond cluster in adhesion. Physical Review E. 78: 021909.

Y. Lin, M. Inamdar and L.B. Freund. 2008. The competition between Brownian motion and adhesion in soft materials.  Journal of the Mechanics and Physics of Solids. 56: 241-250.

Y. Lin and L.B. Freund. 2007. A lower bound on receptor density for stable cell adhesion due to thermal undulations. Journal of Materials Science42: 8904-8910.

Y. Lin and L.B. Freund. 2007. Forced detachment of a vesicle in adhesive contact with a substrate.  International Journal of Solids and Structures. 44: 1927-1938.

Y. Lin and T.C. Ovaert. 2006. Thermal distortion of an anisotropic elastic half-plane and its application in contact problem including frictional heating.  Journal of Tribology. 128: 32-39. 

L.B. Freund and Y. Lin. 2004. The role of binder mobility in spontaneous adhesive contact and implications for cell adhesion.  Journal of the Mechanics and Physics of Solids. 52: 2455-2472.

Y. Lin and T.C. Ovaert. 2004. Indentation of an anisotropic half-space by a heated punch. Journal of Applied Mechanics. 71:  266-272.

Y. Lin and T.C. Ovaert. 2004. A rough surface contact model for general anisotropic materials. Journal of Tribology. 126:  41-49. 

D.A. Shi, Y. Lin and T.C. Ovaert. 2003. Indentation of an orthotropic half space by a rigid ellipsoidal indenter. Journal of Tribology. 125: 223-231. 

Y. Lin and J. Li. 2002. Deploying dynamics analysis of gravity-gradient stabilized satellite. Engineering Mechanics. 19: 135-139. 








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