Yin, G. and Yuan, Y. (2009). Bayesian model averaging continual reassessment method in phase I clinical trials. Journal of American Statistical Association 104, 954-968.

New release of user-friendly software. For the latest version of , please download it from M. D. Anderson Cancer Center.

This robust design solves the arbitrariness and subjectivity of the prespecified toxicity probabilities in the CRM.

Yin, G. and Yuan, Y. (2009). Bayesian dose finding in oncology for drug combinations by copula regression. Journal of Royal Statistical Society C - Applied Statistics 58, 211-224.

This Bayesian copula-type dose-finding design searches for the MTD (maximum tolerated dose) with two or more drugs combined, each with several predefined dose levels.

Software download: Windows version and readme.

Phase I/II drug-combination trial design with adaptive randomization.

This seamless phase I/II trial design is to identify the most efficacious dose combination which also satisfies certain safety requirements for drug combinations. Multiple MTDs may be identified in phase I and a new Bayesian adaptive randomization is developed to favor more efficacious treatment arms in phase II.

Software download: Windows version and readme.