Clive Lo, PhD
Associate Professor
School of Biological Sciences
The University of Hong Kong
7N-04 Kadoorie Biological Sciences Building
Pokfulam Road, Hong Kong
CHINA
Email: clivelo@hku.hk; Tel: (852) 2299-0337
7N-04 PLANT SCIENCE LABORATORY MEMBERS
EDUCATION
PhD (Botany and Plant Pathology), Purdue University, West Lafayette, Indiana, USA
BSc and MPhil (Biology), The Chinese University of Hong Kong, Shatin, Hong Kong
PREVIOUS POSITIONS
Assistant Professor, School of Biological Sciences and Department of Botany, The University of Hong Kong
Research Assistant Professor, Department of Botany, The University of Hong Kong
Research Scientist, Paradigm Genetics Inc., Research Triangle Park, North Carolina, USA
TEACHING (2011-2012)
BIOL1125 Introduction to Biochemistry
BIOL2112 Plant Physiology
BIOL2117 Genetics II
RESEARCH INTERESTS
Plant secondary metabolism and metabolic engineering
Biochemistry and molecular biology of plant-pathogen interactions and plant stress responses
PUBLICATIONS (*corresponding authorship)
Lam MPY, Lau E, Siu SO, Ng DCM, Lo C, Chu IK (2011) Online combination of reverse-phase-reverse-phase and porous graphitic carbon liquid chromatography for multi-component separation of proteomics and glycoproteomics samples. Electrophoresis 32:2930-2940.
Kong RPW, Siu SO, Lo C*, Chu IK* (2011) Development of online high-/low-pH reverse-phase/reverse-phase two-dimensional liquid chromatography for shotgun proteomics: A reverse-phase-strong cation exchange-reverse-phase approach. Journal of Chromatograph A 1218:3681-3688.
Lau E, Lam MPY, Siu SO, Kong RPW, Chan WL, Zhou Z, Huang J, Lo C*, Chu IK* (2011) Combinatorial use of offline SCX and online RP-RP liquid chromatography for iTRAQ-based quantitative proteomics applications. Molecular Biosystems 7:1399-1408.
Du Y, Chu H, Chu IK, Lo C* (2010) CYP93G2 is a flavanone 2-hydroxylase required for C-glycosyl-flavone biosynthesis in rice. Plant Physiology 154:324-333.
Liu H, Du Y, Chu H, Shih CH, Wong YW, Wang M, Chu IK, Tao Y, Lo C* (2010) Molecular dissection of the pathogen-inducible 3-deoxyanthocyanidin pathway in sorghum. Plant and Cell Physiology 51:1173-1185.
Liu H, Lau E, Lam M, Chu H, Li S, Huang G, Guo P, Wang J, Jiang L, Chu IK, Lo C*, Tao Y* (2010) OsNOA1/RIF1 is a functional homolog of AtNOA1/RIF1: implication for a highly conserved plant cGTPase essential for chloroplast functions. New Phytologist 187:83-105.
Zeng X, Kong R, Cheng, KW, Du Y, Tang YS, Chu IK, Lo C, Sze, KH, Chen, F, Wang M* (2010) Direct Trapping of Acrylamide as a Key Mechanism for Niacin’s Inhibitory Activity in Carcinogenic Acrylamide Formation. Chemical Research in Toxicology 23:802-807.
Du Y, Chu H, Wang M, Chu IK, Lo C* (2010) Identification of flavone phytoalexins and a pathogen-inducible flavone synthase II gene in sorghum. Journal of Experimental Botany 61:983-94.
Zeng XH, Cheng KW, Du Y, Kong R, Lo C, Chu IK, Chen F, Wang M (2010) Activities of hydrocolloids as inhibitors of acrylamide formation in model systems and fried potato strips. Food Chemistry 121: 424-428.
Cheng KW, Yang RY, Tsou SCS, Lo C, Ho CT, Lee TC, Wang M (2009) Analysis of antioxidant activity and antioxidant constituents of Chinese toon. Journal of Functional Foods 1: 253-259.
Cheng KW, Wong CC, Chao J, Lo C, Chen F, Chu IK, Ho CT, Wang M (2009) Inhibition of mutagenic PhIP formation by EGCG via scavenging of phenylacetaldehyde. Molecular Nutrition & Food Research 53: 716-725.
Tang LK, Chu H, Yip WK, Yeung EC, Lo C* (2009) An anther specific dihydroflavonol 4-reductase-like gene (DRL1) is essential for male fertility in Arabidopsis. New Phytologist 181: 576-587. (selected for cover image)
Lo C*, Nicholson RL (2008) Phenolic compounds and their importance in plant diseases. In: Leite B, Pascholati SF, Stangarlin JR, Cia P, eds, INTERAÇÃO PLANTA-PATÓGENO Fisiologia, Bioquímica e Biologia Molecular (Physiology, Biochemistry and Molecular Biology of Plant-Pathogen Interactions). FEALQ: Piracicaba, Sao Paulo. pp. 285-303. (Invited Book Chapter)
Shih CH, Chu H, Tang LK, Sakamoto W, Maekawa M, Chu IK, Wang M, Lo C* (2008) Functional characterization of key structural genes in rice flavonoid biosynthesis. Planta 228: 1043-1054.
Cheng KW, Wong CC, Cho CK, Chu IK, Sze KH, Lo C, Chen F, Wang M (2008) Trapping of phenylacetaldehyde as a key mechanism responsible for naringenin's inhibitory activity in mutagenic 2-Amino-1-methyl-6-phenylimidazo [4,5-b] pyridine formation. Chemical Research in Toxicology 21: 2026-2034.
Shih CH, Chen Y, Wang M, Chu I, Lo C* (2008) Accumulation of isoflavone genistin in transgenic tomato plants over-expressing a soybean isoflavone synthase gene. Journal of Agricultural and Food Chemistry 56: 5655-5661.
Peng C, Cheng KW, Ma J, Chen B, Ho CT, Lo C, Chen F, Wang M (2008) Cinnamon bark proanthocyanidins as reactive carbonyl scavengers to prevent the formation of advanced glycation endproducts. Journal of Agricultural and Food Chemistry 56: 1907-1911.
Yu CKY, Shih CH, Chu IK, Lo C*(2008) Accumulation of trans-piceid in sorghum seedlings infected with Colletotrichum sublineolum. Phytochemistry 69: 700-706.
Lo C*, Le Blanc Y, Yu CKY, Sze KH, Ng DCM, Chu IK (2007) Detection, characterization, and quantification of resveratrol glycosides in transgenic Arabidopsis over-expressing a sorghum stilbene synthase gene by liquid chromatography tandem mass spectrometry. Rapid Communications in Mass Spectrometry 21: 4101-4108.
Shih CH, Siu SO, Ng R, Wong E, Chiu LCM, Chu IK, Lo C* (2007) Quantitative analysis of anticancer 3-deoxyanthocyanidins in infected sorghum seedlings. Journal of Agricultural and Food Chemistry 55: 254-259.
Shih CH, Chu IK, Yip WK, Lo C* (2006) Differential expression of two flavonoid 3'-hydroxylase cDNAs involved in the biosynthesis of anthocyanin pigments and 3-deoxyanthocyanidin phytoalexins in sorghum. Plant and Cell Physiology 47:1412-1419.
Yu CKY, Lam CNW, Springob K, Schmidt J, I Chu, Lo C* (2006) Constitutive accumulation of cis-piceid in transgenic Arabidopsis over-expressing a sorghum stilbene synthase gene. Plant and Cell Physiology 47:1017-1021.
Yu CKY, Springob K, Schmidt J, Nicholson RL, Chu IK, Yip WK, Lo C * (2005) A stilbene synthase gene is involved in host and non-host defense responses in Sorghum bicolor. Plant Physiology 138: 393-401.
Lo C , Wang MN, Lam E* (2005) Characterization of inducible gene silencing and recovery in transgenic plants with a vector designed for high-throughput analysis for gene functions. FEBS Letters 579:1498-1502.
Lo C*, Adachi K, Shuster JR, Hamer JE, Hamer L (2003) The bacterial transposon Tn7 causes premature termination of mRNA in eukaryotic organisms: TAGKO mutagenesis in filamentous fungi. Nucleic Acids Research 31: 4822-4827.
Lo C, Coolbaugh RC, Nicholson RL* (2002) Molecular characterization and in silico expression analysis of a chalcone synthase gene family in sorghum. Physiological and Molecular Plant Pathology 61: 179-188.
Lo C*, Hamer L, Hamer JE (2002) Molecular characterization of a cystathionine b-synthase gene, CBS1, in Magnaporthe grisea. Eukaryotic Cell 1: 311-314.
Hamer L*, Adachi K, Monetnegro-Chamorro MV, Tanzer M, Mahanty S, Lo C, Tarpey RW, Skalchunes, A, Heiniger R, Frank S, Darveaux B, Lampe DJ, Slater T, Lakshman R, DeZwaan T, Nelson G, Shuster J, Wossener J, Hamer JE. (2001) Gene discovery and gene function assignment in industrial and pathogenic fungi. Proceedings of National Academy of Sciences USA 98: 5110-5115.
Lo C, Ho YS, Buswell JA* (2001) Effect of phenolic monomers on laccase production by the edible mushroom, Pleurotus sajor-caju, and partial characterization of the major laccase component. Mycologia 93: 413-421.
Lo C, de Verdier K, Nicholson RL* (1999) Accumulation of 3-deoxyanthocyanidin phytoalexins and resistance to Colletotrichum sublineolum in sorghum. Physiological and Molecular Plant Pathology 55: 263-273.
Lo C, Hipskind JD, Nicholson RL* (1999) cDNA cloning of a sorghum pathogenesis-related protein (PR-10) and differential expression of defense-related genes following inoculation with Cochiobolus heterostrophus or Colletotrichum sublineolum. Molecular Plant-Microbe Interactions 12: 479-489.
Lo C, Nicholson RL* (1998) Reduction of light-induced anthocyanin accumulation in inoculated sorghum mesocotyls: implications for a compensatory role in the defense response. Plant Physiology 116: 979-989.
Sugui JA, Bonham C, Lo C, Wood KV, Nicholson RL* (1998) MALDI-TOF analysis of mixtures of 3-deoxyanthocyanidins and anthocyanins. Phytochemistry 48: 1063-1066.
Lo C, Weiergang I, Bonham C, Hipskind J, Wood K, Nicholson RL* (1996) Phytoalexin accumulation in sorghum: Identification of a methyl ether of luteolinidin. Physiological and Molecular Plant Pathology 49: 21-31.
UNITED STATES PATENTS
Methods for the identification of inhibitors of asparagine synthase as antibiotics (Patent no. 6,852,484; Feb 8, 2005)
Methods for the identification of inhibitors of threonine synthase as antibiotics (Patent no. 6,806,060; Oct 19, 2004)
Methods for the identification of inhibitors of histidinol-phosphate as antibiotics (Patent no. 6,740,498; May 25, 2004)
Methods for the identification of inhibitors of 3-isopropylmalate dehydratase as antibiotics (Patent no. 6,733,963; May 11, 2004)
Methods for the identification of inhibitors of alpha-aminoadipate reductase as antibiotics (Patent no. 6,723,529; Apr 20, 2004)
Methods for the identification of inhibitors of 5-aminolevulinate synthase as antibiotics (Patent no. 6,689,578; Feb 10, 2004)
Methods for the identification of inhibitors of homocitrate synthase as antibiotics (Patent no. 6,632,631; Oct 14, 2003)
EDITORIAL BOARD MEMBER
Senior Editor, Physiological and Molecular Plant Pathology, Publisher: Elsevier