The University of Hong Kong Chi-Ching TSANG
BSc (Hons); PhD; CBiol; MRSB; MIBMS
Post-doctoral Fellow
Department of Microbiology
Li Ka Shing Faculty of Medicine
The University of Hong Kong
E-mail: microbioct@connect.hku.hk

ORCID ID: 0000-0001-6705-2866


Research Interests:
- Emerging infectious diseases, in particular talaromycosis (by Talaromyces marneffei)
- Discovery & characterisation of novel pathogens, especially fungi and bacteria
- Diagnostic microbiology
- Antimicrobial resistance
- Medical mycology


Awards and Scholarships:
  1. Wong Ching Yee Medical Postgraduate Scholarship, The University of Hong Kong
  2. Y S and Christabel Lung Postgraduate Scholarship, The University of Hong Kong
  3. Mary Sun Medical Scholarship, The University of Hong Kong
  4. YISHAM Scholarship, International Society for Human and Animal Mycology (ISHAM)
  5. Travel Grant (Affiliate/AMSB), Society of Biology
  6. Young ISHAM Travel Grant, International Society for Human and Animal Mycology (ISHAM)
  7. 30th ECCMID Travel Grant (cancelled due to COVID-19), European Society of Clinical Microbiology and Infectious Diseases
Publications:
  1. Lau SKP, He Z, Tsang C-C*, Chan TTY, Luk HKH, Chan E, Li KSM, Fung J, Chow FWN, Tam AR, Chung TWH, Wong SCY, Que T-L, Fung KSC, Lung DC, Wu AKL, Hung IFN, Teng JLL, Wernery U, Hui S-W, Martelli P, Woo PCY. 2021. A sensitive and specific competitive enzyme-linked immunosorbent assay for serodiagnosis of COVID-19 in animals. Microorganisms. 9:1019. doi: 10.3390/microorganisms9051019.

  2. Tsang C-C, Chan K-F, Chan W, Chan JFW, Au-Yeung RKH, Ngan AHY, Lin KPK, Lau SKP, Woo PCY. 2021. Hepatic phaeohyphomycosis due to a novel dematiaceous fungus, Pleurostoma hongkongense sp. nov., and importance of antifungal susceptibility testing. Emerg. Microbes Infect. 10:81–96. doi: 10.1080/22221751.2020.1866955.

  3. Seelbinder B, Chen J, Brunke S, Vazquez-Uribe R, Santhaman R, Meyer AC, de Oliveira Lino FS, Chan K-F, Loos D, Imamovic L, Tsang C-C, Lam RPK, Sridhar S, Kang K, Hube B, Woo PCY, Sommer MOA, Panagiotou G. 2020. Antibiotics create a shift from mutualism to competition in human gut communities with a longer-lasting impact on fungi than bacteria. Microbiome. 8:133. doi: 10.1186/s40168-020-00899-6.

  4. Tsang C-C, Tang JYM, Ye H, Xing F, Lo SKF, Xiao C, Han L, Wu AKL, Ngan AHY, Lay K-C, To Y-N, Sze- DTT, Chim OHY, Hui TWS, Leung CWH, Zhu T, Yao C, Tse BPH, Lau SKP, Woo PCY. 2020. Rare/cryptic Aspergillus species infections and importance of antifungal susceptibility testing. Mycoses. 63:12831298. doi: 10.1111/myc.13158. doi: 10.1111/myc.13158.

  5. Chow FWN, Chan TTY, Tam AR, Zhao S, Yao W, Fung J, Cheng FKK, Lo GCS, Chu S, Aw-Yong K-L, Tang JYM, Tsang C-C, Luk HKH, Wong ACP, Li KSM, Zhu L, He Z, Tam EWT, Chung TWH, Wong SCY, Que T-L, Fung KSC, Lung DC, Wu AKL, Hung IFN, Woo PCY, Lau SKP. 2020. A rapid, simple, inexpensive, and mobile colorimetric assay COVID-19-LAMP for mass on-site screening of COVID-19. Int J Mol Sci. 21:E5380. doi: 10.3390/ijms21155380.

  6. Woo PCY, Tsang C-C, Lau SKP. 2020. Antifungal resistance: an emerging battlefield. Future Microbiol. 15:571–574. doi: 10.2217/fmb-2019-0330.

  7. Tsang C-C, Lau SKP, Woo PCY. 2019. Sixty years from Segretain's description: what have we learned and should learn about the basic mycology of Talaromyces marneffei? Mycopathologia. 184:721–729. doi: 10.1007/s11046-019-00395-y.

  8. Tsang C-C, Tang JYM, Chan K-F, Lee C-Y, Chan JFW, Ngan AHY, Cheung M, Lau ECL, Li X, Ng RHY, Lai CKC, Fung KSC, Lau SKP, Woo PCY. 2019. Diversity of phenotypically non-dermatophyte, non-Aspergillus filamentous fungi causing nail infections: importance of accurate identification and antifungal susceptibility testing. Emerg Microbes Infect. 8:531–541. doi: 10.1080/22221751.2019.1598781.

  9. Lau SKP, Xing F, Tsang C-C*, Tang JYM, Tan YP, Ye H, Lau RWT, Chen JHK, Lo SKF, Woo PCY. 2019. Clinical characteristics, rapid identification, molecular epidemiology and antifungal susceptibilities of Talaromyces marneffei infections in Shenzhen, China. Mycoses. 62:450–457. doi: 10.1111/myc.12887.

  10. Meyer W, Irinyi L, Hoang MTV, Robert V, Garcia-Hermoso D, Desnos-Ollivier M, Yurayart C, Tsang C-C, Lee C-Y, Woo PCY, Pchelin IM, Uhrlas S, Nenoff P, Chindamporn A, Chen S, Hebert PDN, Sorrell TC. 2018. Database establishment for the secondary fungal DNA barcode translational elongation factor 1α (TEF1α). Genome. 62:160–169. doi: 10.1139/gen-2018-0083.

  11. Tsang C-C, Tang JYM, Fong JYH, Kinne J, Lee HH, Joseph M, Jose S, Schuster RK, Tang Y, Sivakumar S, Chen JHK, Teng JLL, Lau SKP, Wernery U, Woo PCY. Ignatzschineria cameli sp. nov., isolated from necrotic foot tissue of dromedaries (Camelus dromedarius) and associated maggots (Wohlfahrtia species) in Dubai. Int J Syst Evol Microbiol. 68:3627–3634. doi:10.1099/ijsem.0.003046.

  12. Zhao Y, Tsang C-C, Xiao M, Chan JFW, Lau SKP, Kong F, Xu Y, Woo PCY. 2018. Yeast identification by sequencing, biochemical kits, MALDI–TOF MS and rep–PCR DNA fingerprinting. Med Mycol. 56:816–827. doi: 10.1093/mmy/myx118.

  13. Wernery U, Tsang C-C*, Hebel C, Damerau A, Kinne J, Cai J-P, Küspert H, Chan K-F, Joseph M, Xue S, Raghavan R, Tang JYM, Syriac G, Lau SKP, Jose S, Woo PCY. 2018. Serodiagnosis of aspergillosis in falcons (Falco spp.) by an Afmp1p-based enzyme-linked immunosorbent assay. Mycoses. 61:600–609. doi:10.1111/myc.12776.

  14. Lau SKP, Wong EYM, Tsang C-C, Ahmed SS, Au-Yeung RKH, Yuen K-Y, Wernery U, Woo PCY. 2018. Discovery and sequence analysis of four deltacoronaviruses from birds in the Middle East reveal interspecies jumping with recombination as a potential mechanism for avian-to-avian and avian-to-mammalian transmission. J. Virol. 92:e00265-18. doi:10.1128/JVI.00265-18.

  15. Tsang C-C, Tang JYM, Lau SKP, Woo PCY. 2018. Taxonomy and evolution of Aspergillus, Penicillium and Talaromyces in the omics era – past, present and future. Comput. Struct. Biotechnol. J. 16:197–210. doi:10.1016/j.csbj.2018.05.003.

  16. Woo PCY, Lau SKP, Tsang C-C, Lau CCY, Wong P-C, Chow FWN, Fong JYH, Yuen K-Y. 2017. Coronavirus HKU15 in respiratory tract of pigs and first discovery of coronavirus quasispecies in 5′-untranslated region. Emerg. Microbes Infect. 6:e53. doi:10.1038/emi.2017.37.

  17. Lau SKP, Tsang C-C, Woo PCY. 2017. Talaromyces marneffei genomic, transcriptomic, proteomic and metabolomic studies reveal mechanisms for environmental adaptations and virulence. Toxins. 9:192. doi:10.3390/toxins9060192.

  18. Tam EWT, Tsang C-C, Lau SKP, Woo PCY. 2016. Comparative mitogenomic and phylogenetic characterization on the complete mitogenomes of Talaromyces (Penicillium) marneffei. Mitochondrial DNA B Resour. 1:941–942. doi:10.1080/23802359.2016.1261610.

  19. Tsang C-C, Xiong L, Poon RWS, Chen JHK, Leung K-W, Lam JYW, Wu AKL, Chan JFW, Lau SKP, Woo PCY. 2016. Gordonia hongkongensis sp. nov., isolated from blood culture and peritoneal dialysis effluent of patients in Hong Kong. Int. J. Syst. Evol. Microbiol. 66:3942–3950. doi:10.1099/ijsem.0.001292.

  20. Tsang C-C, Chan JFW, Pong W-M, Chen JHK, Ngan AHY, Cheung M, Lai CKC, Tsang DNC, Lau SKP, Woo PCY. 2016. Cutaneous hyalohyphomycosis due to Parengyodontium album gen. et comb. nov. Med. Mycol. 54:699–713. doi:10.1093/mmy/myw025.

  21. Woo PCY, Lau SKP, Fan RYY, Lau CCY, Wong EYM, Joseph S, Tsang AKL, Wernery R, Yip CCY, Tsang C-C, Wernery U, Yuen K-Y. 2016. Isolation and characterization of dromedary camel coronavirus UAE-HKU23 from dromedaries of the Middle East: minimal serological cross-reactivity between MERS coronavirus and dromedary camel coronavirus UAE-HKU23. Int. J. Mol. Sci. 17:691. doi:10.3390/ijms17050691.

  22. Lau SKP, Chan JFW, Tsang C-C*, Chan S-M, Ho M-L, Que T-K, Lau Y-L, Woo PCY. 2016. Human oropharynx as natural reservoir of Streptobacillus hongkongensis. Sci. Rep. 6:24419. doi:10.1038/srep24419.

  23. Tsang C-C, Hui TWS, Lee K-C, Chen JHK, Ngan AHY, Tam EWT, Chan JFW, Wu AL, Cheung M, Tse BPH, Wu AKL, Lai CKC, Tsang DNC, Que T-L, Lam C-W, Yuen K-Y, Lau SKP, Woo PCY. 2016. Genetic diversity of Aspergillus species isolated from onychomycosis and Aspergillus hongkongensis sp. nov., with implications to antifungal susceptibility testing. Diagn. Microbiol. Infect. Dis. 84:125–134. doi:10.1016/j.diagmicrobio.2015.10.027.

  24. Teng JLL, Tang Y, Wong SSY, Ngan AHY, Huang Y, Tsang C-C, Choi GKY, Lau SKP, Woo PCY. 2016. Tsukamurella hongkongensis sp. nov. and Tsukamurella sinensis sp. nov., isolated from patients with keratitis, catheter-related bacteraemia and conjunctivitis. Int. J. Syst. Evol. Microbiol. 66:391–397. doi:10.1099/ijsem.0.000733.

  25. Zhao Y, Chan JFW, Tsang C-C*, Wang H, Guo D, Pan Y, Xiao Y, Yue N, Chen JHK, Lau SKP, Xu Y, Woo PCY. 2015. Clinical characteristics, laboratory identification, and in vitro antifungal susceptibility of Yarrowia (Candida) lipolytica isolates causing fungemia: a multicenter, prospective surveillance study. J. Clin. Microbiol. 53:3639–3645. doi:10.1128/JCM.01985-15.

  26. Tam EWT, Tsang C-C, Lau SKP, Woo PCY. 2015. Polyketides, toxins and pigments in Penicillium marneffei. Toxins. 7:4421–4436. doi:10.3390/toxins7114421.

  27. Zhao Y, Tsang C-C, Xiao M, Cheng J, Xu Y, Lau SKP, Woo PCY. 2015. Intra-genomic internal transcribed spacer region sequence heterogeneity and molecular diagnosis in clinical microbiology. Int. J. Mol. Sci. 16:25067–25079. doi:10.3390/ijms161025067.

  28. Tsang C-C, Kinne J, Fung AMY, Jose SV, Lau SKP, Schuster RK, Wernery U, Woo PCY. 2015. First isolation of Ignatzschineria indica in a case of dromedary camel dermal myiasis. J. Camel Pract. Res. 22:25–26. doi:10.5958/2277-8934.2015.00004.1.

  29. Fernando N, Hui S-W, Tsang C-C*, Leung S-Y, Ngan AHY, Leung RWW, Groff JM, Lau SKP, Woo PCY. 2015. Fatal Fusarium solani species complex infections in elasmobranchs: the first case report for black spotted stingray (Taeniura melanopsila) and a literature review. Mycoses. 58:422–431. doi:10.1111/myc.12342.

  30. Lam JYW, Wu AKL, Leung W-S, Cheung I, Tsang C-C, Chen JHK, Chan JFW, Lee RA, Lau SKP, Woo PCY. 2015. Gordonia species as emerging causes of continuous-ambulatory-peritoneal-dialysis-related peritonitis identified by 16S rRNA and secA1 gene sequencing and matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS). J. Clin. Microbiol. 53:671–676. doi:10.1128/JCM.02971-14.

  31. Tsang C-C, Chan JFW, Trendell-Smith NJ, Ngan AHY, Ling IWH, Lau SKP, Woo PCY. 2014. Subcutaneous phaeohyphomycosis in a patient with IgG4-related sclerosing disease caused by a novel ascomycete, Hongkongmyces pedis gen. et sp. nov.: first report of human infection associated with the family Lindgomycetaceae. Med. Mycol. 52:736–747. doi:10.1093/mmy/myu043.

  32.  Woo PCY, Wu AKL, Tsang C-C, Leung K-W, Ngan AHY, Curreem SOT, Lam K-W, Chen JHK, Chan JFW, Lau SKP. 2014. Streptobacillus hongkongensis sp. nov., isolated from patients with quinsy and septic arthritis, and emended descriptions of the genus Streptobacillus and Streptobacillus moniliformis. Int. J. Syst. Evol. Microbiol. 64:3034–3039. doi:10.1099/ijs.0.061242-0.

  33. Tsang C-C, Chan JFW, Ip PPC, Ngan AHY, Chen JHK, Lau SKP, Woo PCY. 2014. Subcutaneous phaeohyphomycotic nodule due to Phialemoniopsis hongkongensis sp. nov. J. Clin. Microbiol. 52:3280–3289. doi:10.1128/JCM.01592-14.

  34. Woo PCY, Ngan AHY, Tsang CCC, Ling IWH, Chan JFW, Leung S-Y, Yuen K-Y, Lau SKP. 2013. Clinical spectrum of Exophiala infections and a novel Exophiala species, Exophiala hongkongensis. J. Clin. Microbiol. 51:260–267. doi:10.1128/JCM.02336-12.

  35. To KKW, Lau SKP, Wu AKL, Lee RA, Ngan AHY, Tsang CCC, Ling IWH, Yuen K-Y, Woo PCY. 2012. Phaeoacremonium parasiticum invasive infections and airway colonization characterized by agar block smear and ITS and β-tubulin gene sequencing. Diagn. Microbiol. Infect. Dis. 74:190–197. doi:10.1016/j.diagmicrobio.2012.06.014.

  36. Woo PCY, Lau SKP, Lam CSF, Lau CCY, Tsang AKL, Lau JHN, Bai R, Teng JLL, Tsang CCC, Wang M, Zheng B-J, Chan K-H, Yuen K-Y. 2012. Discovery of seven novel mammalian and avian coronaviruses in the genus Deltacoronavirus supports bat coronaviruses as the gene source of Alphacoronavirus and Betacoronavirus and avian coronaviruses as the gene source of Gammacoronavirus and Deltacoronavirus. J. Virol. 86:3995–4008. doi:10.1128/JVI.06540-11.

*Co-first authorship

The Universityof Hong Kong