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Dr. B. Chan

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Publications

(Journal Articles / Book Chapters / Patent / Conference Papers)

 

Journal Articles

  • Chan BP, Hui TY, Wong MY, Yip HK, Chan GCF. Mesenchymal stem cell-encapsulated collagen microspheres for bone tissue engineering. (2009) Tissue Engineering, Part C (In press).

  • Au-yeung KL, Sze KY, Sham MH, Chan BP. Development of a micromanipulator-based loading device for mechanoregulation study of human mesenchymal stem cells in 3D collagen constructs. (2009) Tissue Engineering, Part C (In press).

  • Yeung CW, Chan D, Cheah K, Chan BP. Three dimensional culture and embryoid body-free chondrogenic differentiation of mouse embryonic stem cells in collagen microspheres. (2009) Tissue Engineering, Part A (In press).

  • Cheng HW, Tsui K, Cheung KMC, Chan D, Chan BP. Decellularization of chondrocyte-encapsulated collagen microspheres íV A 3D model to study the effects of acellular matrix on stem cell fate. (2009) Tissue Engineering Part C (In press).

  • Lee M, Lo AC, Cheung PT, Wong D, Chan BP. GDNF-secreting HEK293 cells in collagen-alginate composite gel and collagen microspheres embedded in alginate gel íV New carrier designs for drug delivery applications. (2009) Biomaterials 30: 1214-1221.

  • Chan BP, Leong KW. Scaffolding in tissue engineering íV General approaches and tissue-specific considerations (2008) Eur. J Spine 2008; 17 Suppl 4:467-79.

  • Chan BP, So KF. Effects of photochemical crosslinking on microstructure and protein release of collagen . (2008) Acta Biomaterialia 4: 1627-1636.

  • Chan OCM, So KF, Chan BP. Fabrication of nano-fibrous collagen microspheres for protein delivery and effects of photochemical crosslinking on release kinetics. (2008) Journal of Controlled Release 129 (2): 135-43.

  • Chan BP, Li CH, Au-yeung,KL, Sze KY, Ngan AHW. A microplate compression method for elastic modulus measurement of soft and viscoelastic collagen microspheres. (2008) Ann. Biomed Eng 36(7): 1254-1267

  • Hui TY, Cheung KMC, Cheung WL, Chan D, Chan BP. In vitro chondrogenic differentiation of human mesenchymal stem cells in collagen microspheres: Influence of cell seeding density and collagen concentration. Biomaterials 29 (2008) 3201-3212.

  • Wong HL, Wang MX, Cheung PT, Yao KM, Chan BP. A 3D collagen microsphere culture system for GDNF-secreting HEK293 cells with enhanced protein productivity . (2007) Biomaterials 28: 5369-5380.

  • Chan BP, Hui TY, Yeung CW, Li J, Mo I, Chan GCF. Self-assembled collageníVhuman mesenchymal stem cell microspheres for regenerative medicine. Biomaterials 28 (2007) 4652íV4666.

  • Tse THZ, Chan BP, Chan CM, Lam J. Mathematical modeling of guided neurite growth in an engineered conduit with multiple concentration gradients of nerve growth factor (NGF). Annals of Biomedical Engineering (2007) 35 (9): 1561-1572.

  • Chan BP, Hui TY, Chan OC, So KF, Lu W, Cheung KM, Salomatina E, Yaroslavsky A. Photochemical Cross-Linking for Collagen-Based Scaffolds: A Study on Optical Properties, Mechanical Properties, Stability, and Hematocompatibility. Tissue Eng. (2007); 13(1):73-85.

  • Chan BP, Fu SC, Qin L, Rolf C, Chan KM. Supplementation-time dependence of growth factors in promoting tendon healing. Clin Orthop Relat Res. 2006; 448:240-7.

  • Yu RM, Lin CC, Chan PK, Chow ES, Murphy MB, Chan BP, Muller F, Strahle U, Cheng SH. Four-dimensional imaging and quantification of gene expression in early developing zebrafish (Danio rerio) embryos. Toxicol Sci. (2006); 90(2):529-38.

  • Chan BP, So K-F. (2005) Photochemical Crosslinking Improves the Physicochemical Properties of Collagen Scaffolds. J. Biomed Mater Res A 75(3):689-701.

  • Chan BP, Amann C, Yaroslavsky A, Title C, Smink D, Zarins B, Kochevar IE, Redmond RW. (2005) Photochemical repair of Achilles tendon rupture in a rat model. J Surg Res 124: 274-279.

  • Chan BP, Yuen WF, Lee WH, Wong SN, Chung TY, Wu YJ, Pang SF. (2004) Immunomodulating effects of CKBM on the cytokine production in peripheral blood mononuclear cells from healthy volunteers. Immunopharma. Immunotoxicol. 26:1-16.

  • Fu SC, Qin L, Leung CK, Chan BP, Chan KM. (2003) Regular moderate exercise training prevents decrease of CD4+ T-lymphocytes induced by a single bout of strenuous exercise in mice. Can J Appl Physiol. 28(3):370-81.

  • Wong MW, Tang YY, Lee SK, Fu BS, Chan BP, Chan CK. (2003) Effect of dexamethasone on cultured human tenocytes and its reversibility by platelet-derived growth factor. JBJS Am. 85-A(10):1914-20.

  • Fu SC, Wong YP, Chan BP, Pau HM, Cheuk YC, Lee KM, Chan KM. (2003) The roles of bone morphogenetic protein (BMP) 12 in stimulating the proliferation and matrix production of human patellar tendon fibroblasts. Life Sci . 72(26):2965-74.

  • Chan BP, Kochevar IE, Redmond RW. (2002) Enhancement of porcine skin graft adherence using a light-activated process. J Surgical Research 108: 77-84.

  • Fu SC, Chan BP, Wang W, Pau HM, Chan KM, Rolf CG. (2002) Increased expression of matrix metalloproteinase 1 (MMP1) in 11 patients with patellar tendinosis. Acta Orthop Scand 73(6):658-62.

  • Rolf CG, Fu SC, Pau A, Wang W, Chan B. (2001) Increased cell proliferation and associated expression of PDGFRbeta causing hyper cellularity in patella tendinosis. Rheumatology ( Oxford ) 40(3):256-261.

  • Chan BP, Fu SC, Qin L, Lee KM, Rolf CG, Chan KM. (2000) Effects of basic fibroblast growth factor (bFGF) on early stages of tendon healing. Acta Orthop Scand 71(5): 513-518.

  • Chan BP, Fu SC, L Qin, Rolf C, Chan KM (1998) Pyridinoline in relation to ultimate stress of the patellar tendon during healing- An animal study. Journal of Orthopaedic Research 16:597-603.

  • Chan BP, Chan KM, Maffulli N, Webb S, Lee KKH. (1997) Effect of basic fibroblastic growth factor - An in vitro study of tendon healing. Clin Orthop Rel Res 342:239-247.

  • Chan BP, Fu SC, Chan KM. (1997) In vivo model of patellar tendon healing - effect of basic fibroblast growth factor. Med Sci Sports Exe 29(5):S231.

  • Chan BP, Chan KM, Lee KKH, Maffulli N, Webb S. (1996) The effect of basic fibroblast growth factor (bFGF) in tendon healing - An in vitro study. The FASEB Journal supp 10(3):3846.

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Book Chapters

  • Chan KM, Chan BP. R. Rosier, N. Maffulli. Future of Cytokines in Tissue Healing. In Chan KM, F. Fu, N. Maffulli, C. Rolf, M. Kurosaka, Stephen Liu, eds. Controversies in Orthopaedics Sports Medicine. Hong Kong : Williams and Wilkins Asia-Pacific Ltd., 1998:564-576.

  • Chan KM, Hong YL, Li JX, Leung SSF. Health benefits of exercise and diet control in children and adolescents - A Hong Kong and China perspectives. In Chan KM, Michelli L, eds. Sports and Children. Hong Kong : Williams & Wilkins Asia-Pacific. 1998.

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Patent (Issued/Published)

  • Chan BP, Chan CM, So KF. Collagen-based microspheres and methods of preparation and use thereof. US Regular Patent 20080317866 (filed on 2 Jul 2008) (Published on 25 Dec 2008)

  • Chan BP, GCF Chan, Wong HL, Cheung PT, Cheah K, Chan D. Cell-Matrix Microsphere, Associated Products, Methods for Preparation and Applications. US Regular Patent Application No. 11/750,863 (filed on 18 May 2007) (Publication date 7 Feb 2008).

  • Chan BP, K Cheung, GCF Chan, D Chan, TY Hui. Bioengineered intervertebral disc and Methods for Their Preparation. US Regular Patent Application No. 11/742,040 (filed on 30 April 2007) (Publication date 20 Dec 2007)

  • Chan BP, So KF. Photochemically crosslinked collagen scaffolds and methods for their preparation. U.S. Regular Patent No. 7,393,437 (1 Jul 2008)

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Conference Papers (Selected)

  • Wong H.C.T., Wong M.Y., Chan B.P. and Yu A.C.H. Ultrasound-enhanced osteogenesis of human mesenchymal stem cells encapsulated in collagen meshwork, IEEE Ultrasonics Symposium, 2009, accepted.

  • Chik TK, Luk K, Cheung K, Sze KY, Chan BP. Creation of a tissue interface between bone-like construct and soft tissue-like construct. TERMIS 2nd World Congress, Seoul, Korea, Aug 31- 3 Sep 2009. S211: 802.

  • Chik TK, Sze KY, Chan BP. A feasibility study on applying dynamic torsional loading to cylindrical collagen-fibroblast constructs. TERMIS 2nd World Congress, Seoul, Korea, Aug 31- 3 Sep 2009. S211: 801.

  • Li CH, Ngan A, Sze KY, Chan BP. Association between elastic modulus and extracellular matrix components of collagen-mesenchymal stem cell microsphres during chondrogenic differentiation. TERMIS 2nd World Congress, Seoul, Korea, Aug 31- 3 Sep 2009. S210:795. (Best poster presentation award)

  • Yuan MT, Chan BP. Culture of rabbit nucleus pulposus cells in 3D collagen microspheres íV A comparison with traditional 2D culture. TERMIS 2nd World Congress, Seoul, Korea, Aug 31- 3 Sep 2009. S217: 824.

  • Cheng HW, Chan BP. Fabrication of osteochondral composite with intact interface using rabbit mesenchymal stem cells and collagen gel. TERMIS 2nd World Congress, Seoul, Korea, Aug 31- 3 Sep 2009. S234: 893.

  • Choy ATH, Au-yeung C, Tam H, Lau I, Chan BP. Fabrication and characterization of a gel-like collagen-glycosaminoglycan structure for nucleus pulposus replacement. TERMIS 2nd World Congress, Seoul, Korea, Aug 31- 3 Sep 2009. S215: 817.

  • Li YY, Cheng HW, Wong MY, Cheung K, Chan D, Chan BP. Collagen-mesenchymal stem cell microspheres for cartilage tissue engineering. TERMIS 2nd World Congress, Seoul, Korea, Aug 31- 3 Sep 2009. S69:222.

  • Li CH, Sze KY, Chan BP. Microplate manipulation of human mesenchymal stem cells collagen microspheres. WACBE (World Association for Chinese Biomedical Engineers) World Congress on Bioengineering 2009. 26-29 Jul 2009, Hong Kong, China. P65.

  • Cheng HW, Tsui YK, Cheung KMC, Chan D, Chan BP. WACBE (World Association for Chinese Biomedical Engineers) World Congress on Bioengineering 2009. 26-29 Jul 2009, Hong Kong, China. P58.

  • Au-yeung KL, Sze KY, Sham MH, Chan BP. Development of a micromanipulator-based loading device for mechanoregulation study of human mesenchymal stem cells in 3D collagen constructs. WACBE (World Association for Chinese Biomedical Engineers) World Congress on Bioengineering 2009. 26-29 Jul 2009, Hong Kong, China. P53.

  • Wong HL, Wong MY, Chan GCF, Yang ZF, Chan BP. Functionally selecting human mesenchymal stem cell subpopulations with better migratory activities using a collagen barrier. 7th Annual Meeting of International Society for Stem Cell Research, Jul 8-11, 2009. Barcelona, Spain. #1265.

  • Chan BP, Hui TY, Wong MY, Yip HK, Chan GCF. Formation of injectable and osteoinductive bone-like microparticles using mesenchymal stem cell-collagen microspheres. 7th Annual Meeting of International Society for Stem Cell Research, Jul 8-11, 2009. Barcelona, Spain. #1263.

  • Yeung CW, Cheah K, Chan D, Chan BP. Effects of reconstituted collagen matrix on fates of mouse embryonic stem cells before and after induction for chondrogenic differentiation. 7th Annual Meeting of International Society for Stem Cell Research, Jul 8-11, 2009. Barcelona, Spain. #369.

  • Liu T, Choy ATH, Shi L, Chan BP, Chew SY. Acid-Based Electrospinning of Type I Collagen Nanofibers for Neural Tissue Engineering. Biomaterials Asia 2009, 5-8 April, Hong Kong. PB34.

  • Cheng HW, Tsui YK, Cheung KMC, Chan D, Chan BP. Decellularization of chondrocyte-encapsulated collagen microspheres íV A 3D model to study effects of acellular matrix on stem cell fate. Biomaterials Asia 2009, 5-8 April, Hong Kong. PA16.

  • Cheng HW, Luk K, Cheung KMC Chan BP. Optimization of composite medium for simultaneous co-culture of 3D cartilage-like and bone-like constructs. Biomaterials Asia 2009, 5-8 April, Hong Kong. PB15.

  • Li YY, Cheng HW, Chan PM, Wong MY, Chan D, Chan BP. Collagen-mesenchymal stem cell microspheres for cartilage tissue engineering. Biomaterials Asia 2009, 5-8 April, Hong Kong. OD02.

  • Wong HL, Chan GCF, Yang ZF, Chan BP. Functionally selecting hMSCs subpopulations with better migratory activities using a collagen barrier. Biomaterials Asia 2009, 5-8 April, Hong Kong. PA14.

  • Yeung CW, Cheah K, Chan D, Chan BP. Three dimensional culture and chondrogenic differentiation of mouse embryonic stem cells. Biomaterials Asia 2009, 5-8 April, Hong Kong. OB01.

  • Chik TK, Luk K, Cheung K, Sze KY, Chan BP. Creation of a tissue interface between bone-like construct and soft tissue-like construct. Biomaterials Asia 2009, 5-8 April, Hong Kong. PA17.

  • Li CH, Ngan A, Sze KY, Chan BP. Association study between elastic modulus and extracellular matrix components of collagen-mesenchymal stem cell microspheres during chondrogenic differentiation. Biomaterials Asia 2009, 5-8 April, Hong Kong. PA18.

  • Lee M, Lo AC, Cheung PT, Wong D, Chan BP. Drug carrier system based on collagen alginate composite structures for improving the performance of GDNF-secreting HEK293 cells. Biomaterials Asia 2009, 5-8 April, Hong Kong. PA15.

  • Wong MY, Hui TY, Yip HK, Chan GCF, Chan BP. Self-assembled osteoinductive bone-like microparticles. Biomaterials Asia 2009, 5-8 April, Hong Kong. PB16.

  • Chan BP. Collagen-mesenchymal stem cell microspheres for regenerative medicine. World Forum for Spine Research íV The Intervertebral disc. First Japanese Meeting, January 23íV26, 2008, The Westin Miyako Kyoto , Kyoto , Japan.

  • Li CH, Ngan A, Sze KY, Chan BP. Microplate Manipulation of human mesenchymal stem cells (hMSCs) íV collagen microspheres. World Forum for Spine Research íV The Intervertebral disc. First Japanese Meeting, January 23íV26, 2008, The Westin Miyako Kyoto , Kyoto , Japan.

  • Cheng HW, Tsui K, Cheung KMC, Chan D, Chan BP. Decellularization of chondrocyte-encapsulated collagen microspheres. World Forum for Spine Research íV The Intervertebral disc. First Japanese Meeting, January 23íV26, 2008, The Westin Miyako Kyoto , Kyoto , Japan.

  • Chan BP, Hui TY, Yeung CW, Chan GCF. Self-Assembled Collagen-Human Mesenchymal Stem Cell (hMSCs) Microspheres íV Novel Bio-devices for Cell Delivery. The 34th Annual Meeting and Exposition of the Controlled Release Society. 7-11 Jul 2007. Long Beach , California , USA . #566.

  • Chan CM, So KF, Chan BP. Photochemically crosslinked collagen microspheres for controlled protein release. The 34th Annual Meeting and Exposition of the Controlled Release Society. 7-11 Jul 2007. Long Beach , California , USA . #558

  • BP Chan, GCF Chan. Self-Assembled Collagen-Human Mesenchymal Stem Cell (hMSCs) Microspheres íV Novel Bio-devices for Cell Delivery. International Society for Stem Cell Research 5th Annual Meeting. Jun 15-21 2007. Cairns , Queensland , Australia . p59.

  • Hui TY, K Cheung, D Chan, Chan BP. Chondrogenic differentiation of human mesenchymal stem cells in three-dimensional collagen/chondroitin-6-sulfate gels: Influences of cell seeding density and collagen concentration. International Society for Stem Cell Research 5th Annual Meeting. Jun 15-21 2007. Cairns , Queensland , Australia . p155.

  • Yeung CW, Cheah KSE, Chan D, Chan BP. A Novel 3-Dimensional Culture System for Mouse Embryonic Stem Cells. International Society for Stem Cell Research 5th Annual Meeting. Jun 15-21 2007. Cairns , Queensland , Australia . p340.

  • Au-Yeung KL, Sze KY, Chan BP. A setup for mechanoregulation studies of cells in 3D configuration. NANOBIO - TOKYO 2006.

  • Chan CM, So KF, Chan BP. Photochemically crosslinked collagen microspheres for controlled drug release. Proceedings on the Conference on Biomedical Engineering, BME2006, 21-23 Sep, 2006, Hong Kong . P65.

  • Chan BP, Leung MH, Yeung CW, Li J, I Mo, Chan GCF. A Novel 3-Dimensional Culture System for Human Mesenchymal Stem Cells. International Society for Stem Cell Research 4th Annual Meeting. Jun 29-1 July 2006. Toronto , Ontario , Canada . p98.

  • Hui TY, Ho G, Cheung KMC, Chan D, Cheung WL, Chan BP (2005) Rabbit bone marrow derived mesenchymal stem cells induced collagen gel contraction íV Fabrication of multi-layered tissue-like structures with different cell densities. Tissue Engineering 2006 12(4): p1110.

  • Chan BP, So KF. (2005) Modification of the physicochemical properties and microstructures of collagen scaffolds using photochemical crosslinking. Tissue Engineering 2006 12(4): p1016-1017.

  • Chan BP, So KF. (2005) Photochemical crosslinking affects the microstructure of porous collagen scaffolds. Tissue Engineering 2006 12(4): p1070.

  • Chan CM, KF So, Chan BP. (2005) Photochemical crosslinking reduces the intrinsic thrombogenecity of collagen membranes in vitro. Tissue Engineering 2006 12(4): p1087.

  • Chan BP (2005) Modification of the Physicochemical Properties of Collagen Scaffolds using photochemical crosslinking. Regenerate 2005, Atlanta , 1-3 Jun, 2005. A005.

  • Chan BP, Sato M, Vacanti JP, Kochevar IE, Redmond RW. (2005) Photochemical bonding of epithelial cell-seeded collagen lattice to rat muscle layer for esophageal tissue engineering íV a pilot study. In Proceedings of SPIE Volume: 5686C . Laser Welding and Soldering of Tissue, San Jose , California , Jan 22-27, 2005.

  • Chan BP. (2005) A Photochemical Crosslinking Technology for Tissue Engineering - Enhancement of the Physico-Chemical Properties of Collagen-based Scaffolds. In Proceedings of SPIE Volume: 5695. Optical Interactions with Tissue and Cells XVI, San Jose , California , Jan 22-27, 2005.

  • Chan B.P. (2004) Enhancement of the physico-chemical properties of collagen-based scaffold for tissue engineering using a new photochemical crosslinking technology. Gordon Research Conference on Musculoskeletal Biology and Bioengineering. July 24-29 2004. Proctor Academy , New Hampshire , U.S.A.

  • Chan BP, Kochevar IE, Redmond RW. (2001) Photochemical tissue bonding in skin grafting. Annual Congress of European Society of Photobiology. Norway , Sept 3 2001.

  • Chan BP, Redmond RW, Kochevar IE. (2001) Photochemical tissue bonding in skin grafting. Annual Congress of Photochemistry and Photobiology Society. Chicago Jul 2001.

  • Tong C, Chan BP, Fu SC , Qin L, Chan KM. (1999) In vivo effects of platelet-derived growth factor isoform B (PDGFBB) in rat patellar tendon during healing. Annual meeting for ISAKOS. Florida , USA.

  • Chan BP, Fu SC, Qin L, Chan KM. Effect of basic fibroblast growth factor (bFGF) in tendon healing using an alginate gel as the delivery system. 20 th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. ížBiomedical Engineering Towards the Year 2000 and Beyond.íĘ 29 Oct íV 1 Nov. 1998 Hong Kong. P752.

  • Chan BP, Fu SC, Qin L, Chan KM. An in vivo study of the rat patellar tendon healing íV Histological, biochemical and biomechanical aspects. 20 th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. ížBiomedical Engineering Towards the Year 2000 and Beyond.íĘ 29 Oct íV 1 Nov. 1998 Hong Kong. P751.

  • Chan BP, Fu SC, Qin L, Chan KM. An in vivo study of the rat patellar tendon healing - Histological, biochemical and biomechanical aspects. 44 th Annual meeting, Orthopaedic Research Society, New Orleans, Louisiana, 16-19 March 1998. p79.

  • Chan KM, Chan BP, Fu SC. Effect of bFGF on tendon healing - an in vivo model. First Biennial Congress, International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine. 11-16 May 1997. Buenos Aires , Argentina.

  • Chan BP, Fu SC, Qin L, Chan KM. An in vivo model of patellar tendon healing - Histological, Biochemical and Biomechanical aspects. The Second Scientific Congress of the Chinese Speaking Orthopaedic Society, 29 Mar 1997. Shanghai , China . p149.

  • Chan KM, Chan BP, N Maffulli , S Webb, KKH Lee. Patellar tendon fibroblasts response to bFGF - An in vitro study of tendon healing. p708. Abstract Book. 2nd World Congress on Sports Trauma/AOSSM 22nd Annual Meeting. 16-20 June, 1996. Lake Buena Vista , Florida.

  • Chan BP, Fu SC , Cheng CW, Maffulli N, Chan KM. Designing a slow protein-releasing system with alginate gel for growth factor supplementation in wound healing of patellar tendon. p65. Second Asian Congress of Sports Medicine - Asian Sports Medicine and Sports Science: Moving towards the 21st Century. 24-27 January 1996. Manila , Philippines.

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